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Metronidazole has shown proof of mutagenic action in several in vitro bacterial assay programs. In addition, a dose-response rise in the frequency of micronuclei was observed in mice right after intraperitoneal injections and an increase in chromosome aberrations happen to be reported in patients with Crohn's illness who were being dealt with with 200-1200 mg/day of metronidazole for one to 24 months.

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Although these reduced amounts of exposure are not as likely to make the popular ‑reactions found with oral metronidazole, the possibility of these and also other reactions can't be excluded presently.

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The accessible data will not enable the calculation of relevant comparisons between the systemic exposures of metronidazole noticed in animal scientific tests to the systemic exposures that may be predicted in human beings soon after topical utilization of METROGEL.

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